식물분자생물학연구실

: 지도교수김동환Kim, Dong-Hwan; dhkim92@cau.ac.kr

경력 및 수상

2018.03-현재	중앙대학교 생명자원공학부 조교수
2018.02.	The University of Texas at Austin, President’s Staff Award
2013.01-2018.02	The University of Texas at Austin, Research Associate
20012.04.	The University of Texas at Austin, MCDB Retreat, Best presentation Award
2008.02-2012.12	The University of Texas at Austin, Postdoc Fellow
2005.06.	한국 광과학회, 최우수포스터상
2005.09.-2008.01	KAIST, 연수연구원
2004.03-2005.08	서울대학교 식물분자유전육종연구센터 박사후 연구원

주요 연구 분야

본 실험실은 식물의 발달에 주요한 역할을 하는 유전자들의 발현 조절이 어떠한 메카니즘에 의해 이루어지는지, 유전학적, 분자생물학적, 생화학적, 유전체적, 생물정보분석학적 접근 방법들을 다양하게 활용해 연구를 합니다. 특히, 최근에 많은 이슈가 되고 있는 유전자 교정기술 (CRISPR_Cas9 tools), 후성유전학 (Epigenetics)적 연구기법, 차세대시퀀싱(NGS)과 같은 기법들을 활용하고 생물정보학을 이용한 분석을 통해, 식물의 발달 및 생육이 환경에 의해 어떻게 후성유전학적 메커니즘으로 변화, 조절되는지를 유전체적 (genomics) 관점에서 밝히고자 합니다. 더 나아가 밝혀진 연구결과를 토대로 작물에 적용해 생육 및 상품성 등이 향상된 새로운 품종을 개발하는 연구를 하고자 합니다.

연구 주제

1저온의 춘화(Vernalization)에 의한 식물의 개화 (Flowering)기작에 대한 후성유전학적 및 생물정보학적 (bioinformatics) 연구
2광, 온도가 식물의 발달에 미치는 영향에 대한 후성유전학적 (epigenetics) 및 생물정보학적 (bioinformatics) 연구
3작물의 후성유전체 (Epigenomics) 및 후성유전학적 유전자 조절 (epigenetics) 기작 연구

강의 과목

1학부: 일반화학, 식물분자생물학
2대학원: 미정

보유기술자산

논문

D.-H. Kim, Y. Xi, S. Sung (2017) Modular function of long noncoding RNA, COLDAIR, in the vernalization response. pLoS Genetics, 13(7), e1006939.
D.-H. Kim and S. Sung (2017) Vernalization-triggered intragenic loop formation by long noncoding RNAs. Developmental cell, 40, 302–312.
D.-H. Kim and S. Sung (2017) The binding specificity of PHD-finger domain of VIN3 moderates vernalization response. Plant Physiology, 173: 1258-1268.
E.D. Kim, Y. Xiong, Y. Pyo, D.-H. Kim, B. Kang, S. Sung (2017) Spatio-temporal analysis of coding and non-coding transcripts during maize endosperm development.Scientific Reports, 7:3838.
N. Sharma, R. Xin, D.-H. Kim, S. Sung, T. Lange, E. Huq (2016) NFL promotes flowering specifically under short-day in Arabidopsis. Development 143(4): 682-690
YD Jo, Y. Choi, D.H. Kim, BD Kim, BC Kang (2014) Extensive structural variations between mitochondrial genomes of CMS and normal peppers (Capsicum annuum L.) revealed by complete nucleotide sequencing. BMC Genomics 15:561
D.-H. Kim and S. Sung (2014) Polycomb-mediated gene silencing in Arabidopsis thaliana. Mol. Cells37(12): 841-850.
D.-H. Kim and S. Sung (2014) Genetic and Epigenetic Mechanisms Underlying Vernalization Response. The Arabidopsis Book (TAB). 12:e0171. doi: 10.1199/tab.0171. eCollection 2014.
S. Lim, J. Park, N. Lee, J. Jeong, S. Toh, A. Watanabe, J. Kim, H. Kang, D.H. Kim, N. Kawakami, G. Choi (2013)ABA-INSENSITIVE3, ABA-INSENSITIVE5, and DELLAs Interact to Activate the Expression of SOMNUS and Other High-Temperature-Inducible Genes in Imbibed Seeds in Arabidopsis. Plant Cell, 25: 4863-4878.
D.-H. Kim, and S. Sung (2013) Temperature and Plant Development; Vernalization: Competence to flower provided by winter (Chapter 4), WILEY Blackwell, PP79-96, ISBN 978-1-118-30820-2.
D.-H. Kim and S. Sung (2013) The vernalization response in Arabidopsis is coordinated through a VIN3 and FLC gene family regulatory network. Plant Cell,25:454-469.
Y. Hyun, H. Yun, K. Park, H. Ohr, O. Lee, D.-H. Kim, S. Sung and Y. Choi (2013) The catalytic subunit of Arabidopsis DNA polymerase α ensures stable maintenance of histone modification. Development140(1): 156-166.
D.-H. Kim and S. Sung (2012) Environmentally Coordinated Epigenetic Silencing of FLC by Proteins and Long Noncoding RNA Components. Curr. Opin. Plant Biol. 15 (1): 51-56.
D.-H. Kim, S. Sung (2010) The Plant homeo domain finger protein, VIN3-LIKE 2, is necessary for photoperiod-mediated epigenetic regulation of the floral repressor, MAF5. Proc. Natl. Acad. Sci. USA (PNAS), 107: 17029-17034.
D.-H. Kim, B.R. Zografos, S. Sung (2010) Vernalization-mediated VIN3 induction overcomes the LIKE-HETEROCHROMATIN PROTEIN 1/Polycomb Repression Complex 2 -mediated epigenetic repression. Plant Physiol. 154(2) 949-957.
D.-H. Kim and S. Sung (2010) Role of VIN3-like 2 in facultative photoperiodic flowering response in Arabidopsis. Plant Signal Behav. 5 (12): 1672-1673.
D.-H. Kim, B.R. Zografos, S. Sung (2010) Mechanisms underlying vernalization-mediated VIN3 induction in Arabidopsis. Plant Signal Behav. 5 (11): 1457-1459.
D.P. Horvath, S. Sung, D.-H. Kim, W. Chao, J. Anderson (2010) Characterization, expression and function of DORMANCY ASSOCIATED MADS-BOX genes from leafy spurge.Plant Mol. Biol.73(1-2):169-79.
D.-H. Kim, M.R. Doyle, S. Sung, R.M. Amasino (2009) VERNALIZATION: WINTER AND THE TIMING OF FLOWERING IN PLANTS. Annu. Rev. Cell Dev. Biol.25: 277-299.
D.H. Kim, S. Yamaguchi, S. Lim, E. Oh, J. Park, A. Hanada, Y. Kamiya, G. Choi (2008) SOMNUS, a CCCH-type Zinc Finger Protein in Arabidopsis, Negatively Regulates Light-Dependent Seed germination Downstream of PIL5. Plant Cell 20:1260-1277.
D.H.Kim, M. S. Han, H. W. Cho, D. S. Kim, H.-J. Kim, B.-D. Kim (2008) Molecular Cloning of the CaLFY, putative ortholog of pepper FLO/LFY. Mol. Breeding 22:443-453.
D.H. Kim, J.G. Kang, and B.D. Kim. (2007) Isolation and characterization of the cytoplasmic male sterility-associated orf456 gene of chili pepper (Capsicumannuum L.). Plant Mol. Biol. 63: 519-532.
J.H. Han, H.S. Choi, D.H. Kim, H.R. Lee, and B.D. Kim (2006) Biological, physical and cytological properties of pepper mottle virus-SNU1 and its RT-PCR detection. Plant Pathol. J. 22: 155-160.
D.S. Kim, D.H. Kim, J.H. Yoo, and B.D. Kim (2006) Cleaved amplified polymorphic sequence and amplified fragment length polymorphism markers linked to the fertility restorer gene in chili pepper (Capsicum annuumL.) Mol. Cells 21: 135-140.
D.H. Kim, M.S. Han, H.W. Cho, Y.D. Jo, M.C. Cho, and B.D. Kim (2006) Molecular cloning of a pepper gene that is homologous to SELF-PRUNING. Mol. Cells. 22: 89-96.
D.H. Kim and B. D. Kim (2006) The organization of mitochondrial atp6 gene region in male fertile and CMS lines of pepper (Capsicum annuum L.). Curr. Genet. 49: 59-67.
D.H. Kim and B.D. Kim (2005) Development of SCAR markers for early identification of cytoplasmic male sterility genotype in chili pepper (Capsicum annuum L.). Mol. Cells 20: 416-422.
D.H. Kim, J.G. Kang, S.J. Kim, and B.D. Kim. (2001) Identification of coxⅡ and atp6 regions as associated to CMS in Capsicum annuum by using RFLP and long accurate PCR. J. Kor. Soc. Hort. Sci. 42 (2): 121-127.

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